ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AQUEOUS LEAF EXTRACTS OF Gomphrena celosioides AND Momordica charantia

G. M. OLADELE, M. O. ABATAN, J. O OLUKUNLE, B. S. OKEDIRAN

Abstract


This study reports the anti-inflammatory and analgesic properties of aqueous leaf extracts of Gomphrena celosioides and Momordica charantia in rats and mice.  Hot plate latency test and acetic acid induced writhing movement method were used as the model for analgesic evaluation, while the carrageenan-induced rat paw oedema was used as the model for anti-inflammatory activity.  The result of the study revealed that the leaf extracts of the two plants possess anti-inflammatory property as they were found to significantly (p<0.05) inhibit oedema induced by carrageenan in the rat paws.  The leaf extract of Momordica charantia was also found to significantly (p<0.05) increase the reaction time of the mice in hot plate test method, while the number of writhing movement of the mice was also significantly(p<0.05) reduced in dose-dependent manner. Similar result was observed for mice treated with extract of Gomphrena celosioides.  The pilot toxicity study revealed the plants to have appreciable safety margin, but high dose of Momordica charantia could cause purgation in rats.  The results of the study suggest the anti-inflammatory and analgesic effects of the aqueous leaf extracts of the two plants.

 


Keywords


Gomphrena celosioides, Momordica charantia, anti-inflammatory, analgesic property

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References


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