• E. B. JACOBS
  • A. A. OWOADE
  • A. O. TALABI
  • O. O. ONI




Titre, Newcastle disease virus, Maternally-derived antibody, chicks


High maternally-derived antibodies (MDA) against Newcastle disease virus (NDV) in chickens can interfere with active immunity at early age. This study was conducted to assess the titre of MDA in chicks against NDV from two poultry breeder farms. Twenty-six blood samples were collected from day-old chicks randomly selected from two poultry breeding farms and forty blood samples were collected from the parent stocks of the same farms. The vaccination record of the parent stocks were collected while the antibody titres of the birds were estimated using Haemagglutination Inhibition (HI) test. The geometric mean titre (GMT) of MDA against NDV in chicks from Farms 1 and 2 were log 27.2 and log 27.4 respectively while the parent stocks from Farms 1 and 2 had log 27.7 and log 27.9HI units. The percentage of chicks from Farms 1 and 2 with MDA titre above protective level (>log 23) were 90% and 100% respectively. It was concluded that MDA titres against ND virus was high in the chicks therefore vaccination at day one in the hatcheries and farms should be done after the immune status of the chicks are known since high MDA titre during vaccination neutralizes vaccine virus preventing active immunity.



Alexander, D. J. 2001. Newcastle Disease. British Poultry Science, 42: 5-22.

Allan, W. H., Gough, R. F. A. 1974. A standard haemagglutination inhibition test for Newcastle disease: a macro and micro methods. Veterinary Records, 95: 120-123.

Al-Zubeedy, A. Z. 2009. Immune response in day old broiler chicks vaccinated against Newcastle disease virus. Iraqi Journal of Veterinary Sciences, 23 (2):143-146.

Arshad, M., Ajmal, M., Rauf, A., Rizvi, A. R., Naeem, M. 1988. Isolation of Newcastle disease virus from pigeons, starlings and sparrows from Faisalabad and Lahore district, Pakistan. Pakistan Journal of Zoology, 20: 367–371.

Awang, I. P. R., Wan-Ahmed-Kusairy, W. S., Abdul-Razak, J. 1992. Detection of maternal antibody against Newcastle disease virus in chicks using an indirect immunoperoxidase test. Journal of Veterinary Medicine, Malaysia, 4: 19-23.

Chu, H. P., Rizk, J. 1975. The effect of maternal immunity, age at vaccination and doses or live vaccines on immune response to Newcastle disease. Developments in Biological Standards, 28: 451–463.

Coakes, S. J., Steed, L., Dzidic, P. 2006. SPSS version 13.0 for Windows. Wiley Student Edition. Wiley India (P) Ltd., New Delhi-110002, India.

Dipeolu, M. A., Keripe, O. M., Gbadamosi, A. J. 1998. Chick Mortality in indigenous Chicken under Free Range System in Abeokuta, Nigeria. Nigeria Veterinarians, 1(19): 5-11.

Goddard, R. D., Wyeth, P. J., Varney, W. C. 1994. Vaccination of commercial layer chicks against infectious bursal disease with maternally derived antibodies. Veterinary Record, 135: 273-274.

Kumar, K., Singh, K. C. P., Prasad, C. B. 2000. Immune responses to intermediate strain IBD vaccine at different levels of maternal antibody in broiler chickens. Tropical Animal Health Production, 32: 357–360.

Jalil, M. A., Samad, M. A., Islam, M. T. 2009. Evaluation of maternally derived antibodies against Newcastle Disease Virus And Its Effect On Vaccination In Broiler Chicks, Bangladesh Journal of Veterinary Medicine, 7(2): 296 – 302

Manchang, T. K., Abdu, P. A., Saidu, L. 2004. Epidemiology and Clinicopathologic Manifestations of Newcastle Disease in Nigerian Local Chickens. Revue Elev. Med. Pays Trop., 57 (1-2): 35- 39.

Saidu, L. P., Abdu, A., Markus, E. L. 1998. Retrospective Studies on Newcastle Disease in Vaccinated Flocks in Zaria, Nigeria. Student Veterinarians, 17: 27-31.

Saliu, O. J., Sanda, M. E., Audu, S. I. 2009. Adoption of vaccination against Newcastle disease by rural poultry women farmers in the North Central Zone of Nigeria. International Journal of Poultry Science, 8(5): 500-503.

Samad, M. A. 2005. Poultry Science and Medicine, 1st ed., LEP publication. BAU campus, Mymensingh. pp. 170-192.

Underwood, G., Jackson, C., Mackenzie, M., DeLaney, D. 2004. Effect of maternal (passive) antibody on Newcastle disease virus (NDV) replication. Could deviation from the national standard operating procedures (SOPs) contribute to evolution in virus virulence? Proc. 5th Asian Pacific Poultry Health Conference. Ed. AVPA. Surfers Paradise, Queensland, p 9.

Westbury, H. A. 1984. Comparison of the immunogenicity of NDV strains V4, B1 and LaSota in chickens. 1. Tests in susceptible chickens. Australian Veterinary Journal, 61: 5-9.






Original Manuscript